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BEVS Products | Thrombospondin-1
Thrombospondin-1 (TSP-1)
In most cancers, the growth of malignant tumors is dependent upon the development of new blood vessels, or angiogenesis, to provide sufficient blood flow. Tumors achieve this blood vessel growth, or neovascularization, by producing angiogenic factors such as VEGF (Vascular Endothelial Growth Factor) and TGFB (Tumor Growth Factor Beta). Likewise, in healthy tissues neovascularization is held in check by naturally occurring anti-angiogenic factors such as Thrombospondin-1 (TSP-1). TSP-1 is a potent inhibitor of angiogenesis and effectively inhibits a wide variety of angiogenic stimuli, including VEGF, proteins that act via tyrosine kinase receptors, G proteins, serine/threonine kinase receptors and lipids.
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Creating proprietary baculovirus vectors
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